This online session at the UN Science Summit 2025 aims to showcase the transformative impact of these initiatives through the leadership of at least five exceptional researchers. The session will delve into how these leaders leverage their unique skills and experiences to address pressing health challenges, contribute to the United Nations Sustainable Development Goals (SDGs), and enhance health outcomes not only in Africa but globally. By highlighting specific research projects and their implications for health innovation, the session will underscore the importance of local knowledge and expertise in shaping a healthier future.